Key result
Cardiac resynchronization therapy improved left ventricular ejection fraction from 22% to 29% (p=0.04) and decreased the summed rest score from 33 to 21 (p=0.004) at 5 months in patients with DCM.
Why the study?
Does cardiac resynchronization therapy improve hemodynamic parameters, synchrony, and myocardial perfusion in patients with dilated cardiomyopathy?
Cohort (n=20)
Does cardiac resynchronization therapy improve hemodynamic parameters, synchrony, and myocardial perfusion in patients with dilated cardiomyopathy?
Cardiac resynchronization therapy improves left ventricular ejection fraction and myocardial perfusion, particularly in non-ischemic patients with dilated cardiomyopathy.
Answers are grounded in this paper and cite their sources.
CRT may improve LVEF and perfusion in DCM; hypothesis-generating and requires RCTs before practice change.
To evaluate the modification of hemodynamic parameters and of synchrony using radionuclide angiography (RNA), as well as the effect on myocardial perfusion, 20 patients with dilated cardiomyopathy (DCM) were studied before and five months after cardiac resynchronization therapy (CRT),. Interand intraventricular synchronization was assessed by phase analysis. After CRT, left ventricular ejection fraction improved from 22 ± 5% to 29 ± 13%, p=0.04. There was a significant reduction of intraventricular asynchrony in ischemic patients. There was no difference between interand intraventricular asynchrony measured by RNA and echocardiography at baseline nor for the improvement after CRT. The summed rest score (SRS) decreased from 33±14 to 21±12 (p=0.004). SRS reduced from 35±12 to 27±9 (p NS) among ischemic patients, and from 31±17 to 17±11 (p=0.02) among non-ischemic. Radionuclide angiography is a useful method to assess heart failure patients before and after CRT. CRT improves myocardial perfusion mainly in non-ischemic patients.
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A 2008 study conducted a cohort in Dilated cardiomyopathy (n=20). Cardiac resynchronization therapy (CRT) vs. Baseline (before CRT) was evaluated on Left ventricular ejection fraction (p=0.04). Cardiac resynchronization therapy improved left ventricular ejection fraction from 22% to 29% (p=0.04) and decreased the summed rest score from 33 to 21 (p=0.004) at 5 months in patients with DCM.
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