Why the study?
Does intravenous pindolol improve rhythm conversion in a patient with persistent ventricular fibrillation refractory to defibrillation and lidocaine?
Does intravenous pindolol improve rhythm conversion in a patient with persistent ventricular fibrillation refractory to defibrillation and lidocaine?
Intravenous pindolol successfully restored sinus rhythm in a case of refractory ventricular fibrillation during resuscitation.
Answers are grounded in this paper and cite their sources.
May warrant pindolol trial in refractory VF; leaves open efficacy pending controlled studies.
The beneficial effect of a beta-blocking agent (pindolol), given as an adjuvant to DC-shock and lidocaine therapy in a case of heart resuscitation is reported. A 65-year-old female patient was operated for an abdominal aortic aneurysm. At the conclusion of the operation, which was prolonged and difficult, the patient developed alternating ventricular tachycardia and fibrillation. Within a time interval of 50 min electrical defibrillation was performed 20 to 25 times, and as much as 1100 mg of lidocaine was administered. Simultaneously, combined internal/external cardiac massage was performed. The patient's arrhythmia continued to recur after defibrillation until pindolol in dosages of 0.2 mg had been given twice intravenously. A permanent sinus rhythm was then achieved.
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Holmboe et al. (1976) studied this question.
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