Why the study?
Does propranolol hydrochloride suppress persistently recurring ventricular fibrillation in a patient with acute myocardial infarction refractory to standard therapies?
Does propranolol hydrochloride suppress persistently recurring ventricular fibrillation in a patient with acute myocardial infarction refractory to standard therapies?
Propranolol administered by slow intravenous infusion may be effective for suppressing refractory ventricular fibrillation in the setting of acute myocardial infarction.
May support propranolol for refractory VF in AMI after standard failure; leaves open confirmation in prospective trials.
Propranolol hydrochloride suppressed persistently recurring ventricular fibrillation in a patient with acute myocardial infarction after lidocaine, procainamide hydrochloride, and multiple electric shocks had failed. Propranolol must be used with care in the presence of acute myocardial infarction because of its negative inotropic and chronotropic effects. Propranolol should be administered by slow intravenous infusion if procainamide and lidocaine fail to suppress ventricular fibrillation. Rate of flow must be carefully monitored to avoid bradycardia, hypotension, and cardiac failure.
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Edwin L. Rothfeld (1968) studied this question.
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