Key result
Human induced pluripotent stem cell-derived cardiomyocytes accurately detected compounds with direct activity on heart rhythm, including beta-adrenergic agonists and ion channel blockers, demonstrating their utility as an in-vitro model for drug development.
hiPSC-CMs provide a sensitive and specific high-throughput in-vitro model for predicting the effects of drugs on human heart rate during early drug development.
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Supports stem cell-derived cardiomyocyte models for preclinical screening; leaves open clinical translation pending prospective validation.
Sube et al. (2017) studied Drug-induced cardiac effects. 640 FDA-approved drugs vs. DMSO control was evaluated on Change in beating frequency. Human induced pluripotent stem cell-derived cardiomyocytes accurately detected compounds with direct activity on heart rhythm, including beta-adrenergic agonists and ion channel blockers, demonstrating their utility as an in-vitro model for drug development.
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