Key result
Testing of 10 ion channel blockers on human-induced pluripotent stem cell cardiomyocytes demonstrated relevant pharmacology and excellent correlation with current functional cardiac electrophysiological studies.
Why the study?
Do human-induced pluripotent stem cell cardiomyocytes provide a reliable surrogate for preclinical in vitro electrophysiological safety screening?
Do human-induced pluripotent stem cell cardiomyocytes provide a reliable surrogate for preclinical in vitro electrophysiological safety screening?
Human-induced pluripotent stem cell cardiomyocytes on multielectrode arrays demonstrate relevant pharmacology and correlate well with existing functional cardiac electrophysiological studies, offering a reliable surrogate for preclinical safety screening.
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hiPSC-CMs may support in vitro safety screening; leaves open clinical cardiotoxicity translation.
Harris et al. (2013) studied Electrophysiological safety screening. 10 ion channel blocking compounds vs. Other preclinical models and clinical drug concentrations was evaluated on Functional effects on repolarization and depolarization and precipitation of arrhythmias. Testing of 10 ion channel blockers on human-induced pluripotent stem cell cardiomyocytes demonstrated relevant pharmacology and excellent correlation with current functional cardiac electrophysiological studies.
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