Cardiotoxicity evaluation using human embryonic stem cells and induced pluripotent stem cell-derived cardiomyocytes

Figures

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  Fig. 1. The growth curve and transient pulse patterns of hiPSC-CMs and hESC-CMs. a The growth curve of hiPSC-CMs; b The transient pulse patterns of the hiPSC-CMs; c The growth curve of hESC-CMs; d The transient pulse patterns of hESC-CMs. Data are shown as mean ± SEM, n = 4. hESC-CMs human embryonic stem cells-derived cardiomyocytes, hiPSC-CMs human induced pluripotent stem cells-derived cardiomyocytes

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  Fig. 2. The effects of E-4031 on the hiPSC-CMs and hESC-CMs. a The effect of E-4031 on the CI of hiPSC-CMs; b The effect of E-4031 on the transient pulse patterns of the hiPSC-CMs; c The effect of E-4031 on the CI of hESC-CMs; d The effect of E-4031 on the transient pulse patterns of the hESC-CMs, \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ \overline{x}\pm s $$\end{document}x¯±s , n = 3). Data are shown as mean ± SEM, n = 3. hESC-CMs human embryonic stem cells-derived cardiomyocytes, hiPSC-CMs human induced pluripotent stem cells-derived cardiomyocytes

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  Fig. 3. The effects of quinidine on the hiPSC-CMs and hESC-CMs. a The effect of quinidine on the CI of hiPSC-CMs; b The effect of quinidine on the transient pulse patterns of the hiPSC-CMs; c The effect of quinidine on the CI of hESC-CMs; d The effect of quinidine on the transient pulse patterns of the hESC-CMs, \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ \overline{x}\pm s $$\end{document}x¯±s , n = 3). Data are shown as mean ± SEM, n = 3. hESC-CMs human embryonic stem cells-derived cardiomyocytes, hiPSC-CMs human induced pluripotent stem cells-derived cardiomyocytes

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  Fig. 4. The effects of isoprenaline on the hiPSC-CMs and hESC-CMs. a The effect of isoprenaline on the CI of hiPSC-CMs; b The effect of isoprenaline on the transient pulse patterns of the hiPSC-CMs; c The effect of isoprenaline on the CI of hESC-CMs; d The effect of isoprenaline on the transient pulse patterns of the hESC-CMs, \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ \overline{x}\pm s $$\end{document}x¯±s , n = 3). Data are shown as mean ± SEM, n = 3. hESC-CMs human embryonic stem cells-derived cardiomyocytes, hiPSC-CMs human induced pluripotent stem cells-derived cardiomyocytes

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  Fig. 5. The effects of haloperidol on the hiPSC-CMs and hESC-CMs. a The effect of haloperidol on the CI of hiPSC-CMs. b The effect of haloperidol on the transient pulse patterns of the hiPSC-CMs. c The effect of haloperidol on the CI of hESC-CMs. d The effect of haloperidol on the transient pulse patterns of the hESC-CMs, \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ \overline{x}\pm s $$\end{document}x¯±s , n = 3). Data are shown as mean ± SEM, n = 3. hESC-CMs human embryonic stem cells-derived cardiomyocytes, hiPSC-CMs human induced pluripotent stem cells-derived cardiomyocytes