Key result
Multi-electrode array recordings of human induced pluripotent stem cell-derived cardiomyocytes were unable to distinguish agents with low- and high-risk for Torsades de Pointes, yielding a high false-positive rate.
Population
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM)
Design
Preclinical, evaluated blindly
Authors
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hiPSC-CM MEA may aid early proarrhythmic screening; leaves open clinical TdP risk prediction.
While sensitive for detecting electrophysiological changes, MEA recordings of hiPSC-CMs have a high false-positive rate and cannot reliably distinguish between high- and low-risk torsadogenic drugs.
Qu et al. (2015) studied Drug-induced arrhythmia. Pharmacological treatment (15 drugs) vs. Benign compounds was evaluated on Ability to distinguish torsadogenic from benign compounds using MEA recordings. Multi-electrode array recordings of human induced pluripotent stem cell-derived cardiomyocytes were unable to distinguish agents with low- and high-risk for Torsades de Pointes, yielding a high false-positive rate.
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