Key result
Human induced pluripotent stem cell-derived cardiomyocytes can detect repolarization effects elicited by single and multichannel blocking drugs after defining pharmacologic sensitivity.
Population
4 human induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) lines
Design
Preclinical, blinded
Authors
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Hypothesis-generating for hiPSC-CM repolarization assays; leaves open clinical translation pending human validation.
hiPSC-CMs can reliably detect repolarization effects of single and multichannel blocking drugs across different sites and platforms when pharmacologic sensitivity is defined.
Millard et al. (2018) studied Proarrhythmic risk. 8 well-characterized drugs (including E-4031, JNJ303, nifedipine, mexiletine, flecainide, moxifloxacin, quinidine, ranolazine) was evaluated on Concentration-dependent effects on repolarization. Human induced pluripotent stem cell-derived cardiomyocytes can detect repolarization effects elicited by single and multichannel blocking drugs after defining pharmacologic sensitivity.
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