Key result
An automated patch clamp module recording from 384 cells simultaneously achieved success rates of >85% for completed experiments with various cell lines and 52% for stem cell-derived cardiomyocytes.
Population
HEK, CHO, and RBL cell lines expressing hNa V 1.7, hERG, Kir2.1, GABA, or glutamate receptors, and stem…
Design
Preclinical
Authors
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May support scalable automated electrophysiology in research; leaves open validation for stem cell-derived cardiomyocyte applications.
The development of a 384-channel automated patch clamp module enables high-throughput screening of ion channels with high success rates, including in stem cell-derived cardiomyocytes.
Obergrussberger et al. (2015) studied this question. Automated patch clamp module was evaluated on Success rates for completed experiments. An automated patch clamp module recording from 384 cells simultaneously achieved success rates of >85% for completed experiments with various cell lines and 52% for stem cell-derived cardiomyocytes.
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