What question did this study set out to answer?

To quantitatively evaluate muscle echogenicity via ultrasound in patients with idiopathic inflammatory myopathies and determine its correlation with clinical disease activity and histopathology.

April 28, 2023Muscle & Nerve

Correlation of muscle ultrasound with clinical and pathological findings in idiopathic inflammatory myopathies

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Authors

TYTakeshi YoshidaKobe University HYHiroki YamazakiShimane University YNYukako NishimoriNara Medical University

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Implication

Comparative study demonstrates muscle echo intensity correlates with disease activity and pathology in inflammatory myopathies, indicating utility as a noninvasive biomarker.

Key Points

To quantitatively evaluate muscle echogenicity via ultrasound in patients with idiopathic inflammatory myopathies and determine its correlation with clinical disease activity and histopathology.
Assessed 42 patients with idiopathic inflammatory myopathies (17 with inclusion body myositis [IBM] and 25 with non-IBM myopathies) alongside 25 age- and sex-matched rheumatoid arthritis controls.
Acquired axial ultrasound images of the right biceps brachii and vastus medialis to quantify muscle echo intensity (EI).
Correlated quantitative echo intensity measurements with muscle strength, serum creatine kinase levels, and standardized histopathological scores from muscle biopsies.
Muscle echo intensity was significantly elevated in patients with inflammatory myopathies compared to rheumatoid arthritis controls.
In non-IBM myopathy patients, muscle EI significantly correlated with serum creatine kinase (r = 0.66, p < .001), muscle strength (r = -0.73, p < .0001), and CD3+ inflammatory cell counts (r = 0.56, p = .017).
In IBM patients, muscle EI correlated moderately with quadriceps strength (r = -0.53, p = .028), but demonstrated no significant association with CD3+ inflammatory cell infiltration.

Cite This Study

Yoshida et al. (2023) studied this question.

synapsesocial.com/papers/6a75dafa87be37a05b1626c2 https://doi.org/10.1002/mus.27833

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Implication

Comparative study demonstrates muscle echo intensity correlates with disease activity and pathology in inflammatory myopathies, indicating utility as a noninvasive biomarker.

Correlation of muscle ultrasound with clinical and pathological findings in idiopathic inflammatory myopathies

Discussion

Member takes

Implication

Key Points

Cite This Study

Correlation of muscle ultrasound with clinical and pathological findings in idiopathic inflammatory myopathies

Discussion

Member takes

Implication

Key Points

Cite This Study

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