January 1, 1996Biochemistry

Inositol 1,4,5-Trisphosphate-Mediated Ca2+Release from Platelet Internal Membranes Is Regulated by Differential Phosphorylation

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Population

Platelet internal membranes

Comparison

Phosphorylation by endogenous kinases and… vs Dephosphorylated controls

Design

Preclinical

Authors

TQTodd M. QuintonTemple University KBKevin D. BrownUniversity of Florida Health WDWilliam L. DeanUniversity of Louisville

Discussion

Member takes

Implication

May inform cAMP-mediated platelet regulation; leaves open translation to human antithrombotic strategies.

Structured PICO

Population

Platelet internal membranes

Intervention

Phosphorylation by endogenous kinases and exogenous protein kinase A

Comparator

Dephosphorylated controls

Outcome

Rate of InsP3-mediated Ca2+ releasesurrogate

cAMP-dependent phosphorylation of the InsP3 receptor inhibits Ca2+ release in platelets, providing a mechanistic explanation for cAMP-mediated inhibition of platelet activation.

Cite This Study

Quinton et al. (1996) studied this question.

synapsesocial.com/papers/6a75dde67d7eb453cc706ffb https://doi.org/10.1021/bi960128m

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Inositol 1,4,5-Trisphosphate-Mediated Ca2+Release from Platelet Internal Membranes Is Regulated by Differential Phosphorylation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inositol 1,4,5-Trisphosphate-Mediated Ca2+Release from Platelet Internal Membranes Is Regulated by Differential Phosphorylation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider