Live attenuated measles virus induces regression of human lymphoma xenografts in immunodeficient mice
Why the study?
Does live attenuated measles virus induce regression of human lymphoma xenografts in immunodeficient mice?
Population
Severe combined immunodeficient mice with established human B-cell lymphoma xenografts
Comparison
Intratumoral injection of unmodified Edmonston-B… vs UV-inactivated virus
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Demonstrates oncolytic activity in lymphoma xenografts; leaves open clinical translation pending human trials.
Structured PICO
Does live attenuated measles virus induce regression of human lymphoma xenografts in immunodeficient mice?
P
Population
Severe combined immunodeficient (SCID) mice with established human B-cell lymphoma xenografts (aggressive and indolent)
I
Intervention
Intratumoral injection of unmodified Edmonston-B strain of measles virus (MV-Ed) or genetically modified MVlacZ, as well as intravenous administration of MV
C
Comparator
UV-inactivated virus
O
Outcome
Tumor regression or progressionsurrogate
Live attenuated measles virus demonstrates oncolytic activity against human B-cell lymphoma xenografts in vivo, suggesting potential as a novel replicating-virus therapy.
Cite This Study
Grote et al. (2001) studied this question.