GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons
Key result
Central administration of the GLP-1 receptor agonist Exendin-4 in mice increased heart rate and diminished heart rate variability by decreasing neurotransmission to cardiac vagal neurons.
Authors
Discussion
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Member takes
Implication
May inform mechanisms of GLP-1 effects on autonomic tone; leaves open translation to human cardiovascular outcomes.
PICO
P
Population
Mice assessed for heart rate and heart rate variability during central Exendin-4 administration.
I
Intervention / Comparator
Exendin-4 (Ex-4)
O
Primary Outcome
heart rate and heart rate variability
Cite This Study
Griffioen et al. (2010) studied this question. Exendin-4 (Ex-4) was evaluated on heart rate and heart rate variability. Central administration of the GLP-1 receptor agonist Exendin-4 in mice increased heart rate and diminished heart rate variability by decreasing neurotransmission to cardiac vagal neurons.