Why the study?
Does growth hormone substitution therapy improve myocardial structure and function in adults with hypopituitarism and growth hormone deficiency?
Population
20 adults with hypopituitarism and growth hormone deficiency developed in adulthood due to pituitary or…
Comparison
Growth hormone substitution therapy. vs Placebo (n=10).
Follow-up
1 year (plus 3 months post-withdrawal)
Authors
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May support GH replacement for cardiac benefits in hypopituitarism; hypothesis-generating and should not change practice without RCTs.
Does growth hormone substitution therapy improve myocardial structure and function in adults with hypopituitarism and growth hormone deficiency?
Growth hormone replacement therapy in adults with hypopituitarism enhances cardiac function, increases cardiac mass, and reverses diastolic abnormalities.
Valcavi et al. (1995) studied this question.
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