First-third ejection fraction at rest compared with exercise radionuclide angiography in assessing patients with coronary artery disease.

To compare two methods of evaluating patients with coronary artery disease, the authors assessed the ejection fraction (EF) during the first-third (1/3) of systole by first-pass radionuclide angiography and the EF response to exercise in 22 normal individuals and 40 patients. The 1/3 EF was calculated by averaging 3--5 beats on the time--activity curve. Exercise EFs were obtained by gated cardiac imaging. The results are shown below, including the per cent change in EF with exercise (% EF). (Formula: see text) p less than 0.05 vs. normals; p less than 0.001 vs. normals; all results are +/- SD. Thirty per cent of patients had a depressed EF, 98% had a depressed 1/3 EF, and 88% had an abnormal EF response to exercise. It is concluded that the 1/3 EF by first-pass radionuclide angiography at rest may be at least as sensitive in identifying patients with coronary artery disease as the EF response to exercise.