Key result
Normal-weight adolescents with PCOS had significantly higher serum adipsin levels (58.1 ng/mL) compared to both obese adolescents with PCOS (37.0 ng/mL) and healthy controls (49.7 ng/mL).
Why the study?
Polycystic ovary syndrome is linked to obesity and chronic inflammation, but adipsin levels and their relationship with obesity in adolescents with PCOS had not been investigated.
Are serum adipsin levels altered in normal-weight and obese adolescents with PCOS compared to healthy controls?
Cross-Sectional (n=120)
No
Are serum adipsin levels altered in normal-weight and obese adolescents with PCOS compared to healthy controls?
Absolute Event Rate: 58.1% vs 37%
p-value: p=<0.001
Adipsin levels are significantly elevated in normal-weight adolescents with PCOS and may serve as an independent risk factor or diagnostic aid in this subgroup.
May inform PCOS subtyping in adolescents; leaves open adipsin's role as biomarker pending prospective validation.
Polycystic ovary syndrome (PCOS) is a chronic and heterogeneous disease associated with obesity, hyperinsulinemia, dyslipidemia and chronic low-grade inflammation. Adipsin is a protein that is mostly secreted from adipose tissue and is a structural homolog of complement factor D, the rate-limiting enzyme of the alternative complement system. The aim of this study was to investigate adipsin levels in adolescents with PCOS and their relationship with obesity. 40 normal weight--children with PCOS and 40 obese-children with PCOS, and 40 normal weight healthy children participated in our study. Adipsin levels of adolescents in each group was measured in morning fasting blood samples by a commercial ELISA kit. Adipsin levels showed statistically significant differences between the groups. (p<0.001). Normal-weight PCOS adolescents had higher adipsin levels than both obese PCOS and healthy controls. A negative correlation was observed between adipsin levels and BMI in the PCOS group (r=-0,457, p<0,001). In conclusion, adipsin can be considered as an independent risk factor in normal weight adolescents with PCOS and may help in the diagnosis of PCOS in normal weight children with other symptoms.
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Emiral et al. (2024) conducted a cross-sectional in Polycystic Ovary Syndrome (PCOS) (n=120). Normal-weight PCOS vs. Obese PCOS and healthy controls was evaluated on Serum adipsin levels (ng/mL) (p=<0.001). Normal-weight adolescents with PCOS had significantly higher serum adipsin levels (58.1 ng/mL) compared to both obese adolescents with PCOS (37.0 ng/mL) and healthy controls (49.7 ng/mL).
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