Effects of Exercise Training on Biomarkers of Endothelial Function and Inflammation in Coronary Artery Disease Patients

Purpose to assess the effects of exercise training on biomarkers of endothelial function and inflammation. Methods 47 patients after acute myocardial infarction were randomized to an exercise‐training group (ETG) receiving an 8‐week aerobic exercise programme (3× per week) or to a control group (CG) receiving usual care. At baseline and after 8 weeks the circulating levels of soluble intercellular adhesion molecule‐1 (sICAM‐1) and vascular cell adhesion molecule‐1 (sVCAM‐1), C‐reactive protein (CRP), interleukin (IL)‐6 and ‐10 were assessed. Results ETG increased the circulating levels of IL‐10. Conversely, CG did not change the inflammatory biomarkers, but increased the endothelial dysfunction (). Changes in the inflammatory and endothelial function biomarkers [median (percentile 25 th –75 th )] ETG CG Baseline Final Baseline Final CRP (mg/L) 1.1 (0.5–2.2) 1.4 (0.5–2.4) 0.9 (0.5–1.7) 0.9 (0.7–1.9) IL‐6 (pg/mL) 2.5 (1.6–3.2) 3.13 (2.1–5.0) 3.6 (1.7–6.5) 3.5 (2.8–4.7) IL‐10 (pg/mL) 5.8 (2.6–9.1) 6.36 (4.1–14.7) 7.7 (4.4–17.2) 7.3 (2.9–10.2) sICAM‐1 (ng/mL) 169 (143–209) 187 (154–201) 180 (147–219) 206 (169–242) sVCAM‐1 (ng/mL) 297 (223–377) 340 (269–418) 245 (179–304) 341 (231–424) Different from baseline, P<.05 Conclusions Exercise‐training revealed an anti‐inflammatory effect, expressed by the IL‐10 increase, and counteracted the endothelial function deterioration.