Key result
Multiple sclerosis admission was associated with a higher 1-year hazard of depression readmission compared to asthma (HR 1.37; 95% CI 1.00-1.86; p=0.0485) and rheumatoid arthritis.
Why the study?
The study was designed to assess readmissions for depression or suicide attempt after MS admission compared with other chronic inflammatory illnesses.
Does an index admission for multiple sclerosis increase the risk of readmission for depression or suicide attempt compared to asthma or rheumatoid arthritis?
Cohort (n=104,973)
Yes
Does an index admission for multiple sclerosis increase the risk of readmission for depression or suicide attempt compared to asthma or rheumatoid arthritis?
Hazard Ratio: 1.37 (95% CI 1–1.86)
Absolute Event Rate: 0.5% vs 0.3%
p-value: p=0.0485
Patients hospitalized for multiple sclerosis have a significantly higher risk of subsequent readmission for depression compared to those hospitalized for asthma or rheumatoid arthritis.
MS admission may link to higher depression readmission risk than asthma or RA; leaves open causal mechanisms and screening needs in prospective studies.
Objective: Assess readmissions for depression or suicide attempt (SA) after MS admission versus other chronic inflammatory illnesses. Methods: This retrospective cohort study identified MS, asthma, rheumatoid arthritis (RA), depression, and SA in the 2013 National Readmissions Database by International Classification of Diseases codes. Index admissions (MS, n = 7698; asthma, n = 93,590; RA, n = 3685) and depression or SA readmission rates were analyzed. Hazard ratios (HRs) estimated 1-year depression/SA readmission hazard, comparing MS to asthma or RA, adjusting for age, sex, psychiatric comorbidity, substance abuse, tobacco use, income, and index hospitalization characteristics. Results: MS had more baseline depression (24.7%) versus asthma (15.6%) and RA (14.6%). Ninety-day depression readmission rate was higher in MS (0.5%) than asthma (0.3%) and RA (0.03%). Depression readmission HR was higher after MS admission versus asthma (HR = 1.37, 95% confidence interval (CI) = 1.00–1.86, p = 0.0485) and RA (HR = 4.68, 95% CI = 1.60–13.62, p = 0.0047). HR was not different for SA readmission across groups. Depression readmission HR was more than double in MS patients with psychiatric disease or substance abuse versus RA or asthma patients with either comorbidity. Conclusion: Depression readmission risk after MS hospitalization was elevated versus asthma/RA. Substance use and baseline psychiatric comorbidity were more strongly associated with depression readmission in MS patients.
No takes yet. Share an insight, caveat, or question.
Schorr et al. (2021) conducted a cohort in Multiple sclerosis (n=104,973). Multiple sclerosis vs. Asthma or rheumatoid arthritis was evaluated on 1-year depression readmission (HR 1.37, 95% CI 1.00-1.86, p=0.0485). Multiple sclerosis admission was associated with a higher 1-year hazard of depression readmission compared to asthma (HR 1.37; 95% CI 1.00-1.86; p=0.0485) and rheumatoid arthritis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: