Giant cell tumor (“osteoclastoma”) of the pancreas: A tumor of epithelial origin

Carcinomas of the pancreas with giant cells are not rare, but those containing osteoclast-like tumor cells are quite unusual. This report documents a pancreatic neoplasm comprising both easily recognizable well-differentiated adenocarcinoma and osteoclast-like tumor. The literature on the "osteoclastoma" of the pancreas is reviewed. Evidence for its epithelial deviation is supported strongly by the present case.