April 1, 1976Experimental Biology and Medicine
Reduction of Experimental Myocardial Infarct Size with Hyperosmolar Mannitol
Why the study?
Does hypertonic mannitol reduce infarct size in dogs with temporary circumflex artery occlusion and reflow?
Population
Dogs with ischemic injury produced by proximal occlusion of the circumflex artery for 40 min
Comparison
Hypertonic mannitol infusion beginning just… vs Isotonic saline infusion
Design
Preclinical
Follow-up
48 hours
Authors
Discussion
Loading...
Member takes
Implication
Caution against clinical use; leaves open translation of infarct size reduction to human myocardial infarction.
Structured PICO
Does hypertonic mannitol reduce infarct size in dogs with temporary circumflex artery occlusion and reflow?
P
Population
Dogs with ischemic injury produced by proximal occlusion of the circumflex artery for 40 min
I
Intervention
Hypertonic mannitol infusion beginning just prior to, during, and for a short period after the release of the circumflex coronary artery occlusion
C
Comparator
Isotonic saline infusion
O
Outcome
Infarct size assessed by morphologic techniques after 48 hours of reflowsurrogate
Hypertonic mannitol reduces myocardial infarct size in a canine model of ischemia-reperfusion.
Cite This Study
Kloner et al. (1976) studied this question.