Key result
Intravenous GGF2 treatment significantly improved left ventricular fractional shortening in rats with myocardial infarction compared to vehicle (43.6% vs 36.6%, p=0.0001).
Why the study?
Does GGF2 improve left ventricular systolic function in rats with myocardial infarction?
Does GGF2 improve left ventricular systolic function in rats with myocardial infarction?
Absolute Event Rate: 43.6% vs 36.6%
p-value: p=0.0001
In a rat model of myocardial infarction, GGF2 treatment improves left ventricular systolic function and normalizes gene and protein expression related to energy production.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating for GGF2 in post-MI systolic dysfunction; larger studies needed before clinical translation.
Hill et al. (2013) studied Myocardial Infarction (n=91). Glial Growth Factor 2 (GGF2) vs. Vehicle (sterile GGF2 diluent) was evaluated on Left ventricular fractional shortening (FS%) at 35 days post-MI (p=0.0001). Intravenous GGF2 treatment significantly improved left ventricular fractional shortening in rats with myocardial infarction compared to vehicle (43.6% vs 36.6%, p=0.0001).
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