Design
Review
Key result
Chronic catecholamine stimulation of beta-adrenoceptors mediates adverse myocardial remodeling and heart failure through various signaling pathways.
Authors
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Supports beta-blocker use in HF; leaves open pathway-specific targets for novel therapies.
A full understanding of beta-AR-mediated cardiac remodeling mechanisms could indicate novel therapeutic targets for heart failure.
Yongnan Fu (2011) conducted a review in Heart failure and cardiac pathological remodeling. Chronic adrenergic stimulation was evaluated. Chronic catecholamine stimulation of beta-adrenoceptors mediates adverse myocardial remodeling and heart failure through various signaling pathways.