Key result
Curcumin demonstrated potential cardioprotective effects against chemotherapy-induced cardiotoxicity in most nonclinical studies, primarily by modulating antioxidant capacity and cell death.
Why the study?
Anticancer drugs cause severe cardiotoxicity, and curcumin may affect chemotherapy-induced cardiotoxicity given turmeric extract's observed positive effects on cardiac cells.
Does curcumin protect against chemotherapy-induced cardiotoxicity in nonclinical models?
Systematic Review (n=25)
Does curcumin protect against chemotherapy-induced cardiotoxicity in nonclinical models?
Curcumin shows potential cardioprotective effects against chemotherapy-induced cardiotoxicity in nonclinical models, though some contradictory evidence exists requiring further study.
Answers are grounded in this paper and cite their sources.
Curcumin shows cardioprotective potential in most nonclinical studies; leaves open clinical translation pending human trials.
BACKGROUND: Various anticancer drugs are effective therapeutic agents for cancer treatment; however, they cause severe toxicity in body organs. Cardiotoxicity is one of the most critical side effects of these drugs. Based on various findings, turmeric extract has positive effects on cardiac cells. OBJECTIVE: This study aims to evaluate how curcumin, as the main component of turmeric, may affect chemotherapy- induced cardiotoxicity. METHODS: A database search was performed up to April 2021 using "curcumin OR turmeric OR Curcuma longa" and "chemotherapy-induced cardiac disease", including their equivalents and similar terms. After screening the total articles obtained from the electronic databases, 25 relevant articles were included in this systematic review. RESULTS: The studies demonstrate lower body weight and increased mortality rates due to doxorubicin administration. Besides, cancer therapeutic agents induced various morphological and biochemical abnormalities compared to the non-treated groups. Based on most of the obtained results, curcumin at nontoxic doses can protect the cardiac cells mainly through modulating antioxidant capacity, regulation of cell death, and antiinflammatory effects. Nevertheless, according to a minority of findings, curcumin increases the susceptibility of the rat cardiomyoblast cell line (H9C2) to apoptosis triggered by doxorubicin. CONCLUSION: According to most nonclinical studies, curcumin could potentially have cardioprotective effects against chemotherapy-induced cardiotoxicity. However, based on limited, contradictory findings demonstrating the function of curcumin in potentiating doxorubicin-induced cardiotoxicity, well-designed studies are needed to evaluate the safety and effectiveness of treatment with new formulations of this compound during cancer therapy.
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Armandeh et al. (2022) conducted a systematic review in Chemotherapy-induced cardiotoxicity (n=25). Curcumin vs. Non-treated groups was evaluated on Chemotherapy-induced cardiotoxicity. Curcumin demonstrated potential cardioprotective effects against chemotherapy-induced cardiotoxicity in most nonclinical studies, primarily by modulating antioxidant capacity and cell death.
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