Key result
Turmeric extract ameliorated doxorubicin-induced cardiac, hepatic, and renal toxicities in rats, inhibiting increases in plasma cholesterol, LDH, and CK.
Why the study?
Does turmeric extract prevent doxorubicin-induced cardiac, hepatic, and renal toxicity in rats?
Population
Rats with doxorubicin (DOX)-induced cardiac, hepatic, and renal toxicity
Comparison
Turmeric extract (Curcuma longa) vs Doxorubicin alone (implied)
Design
Preclinical
Authors
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Hypothesis-generating in rat models; leaves open translation to human doxorubicin cardiotoxicity prevention.
Does turmeric extract prevent doxorubicin-induced cardiac, hepatic, and renal toxicity in rats?
Turmeric extract demonstrates protective effects against doxorubicin-induced cardiotoxicity, hepatotoxicity, and nephrotoxicity in a rat model, likely acting as a free radical scavenger.
Mohamad et al. (2009) studied Doxorubicin-induced toxicity. Turmeric extract was evaluated on Cardiac, hepatic, and renal toxicities. Turmeric extract ameliorated doxorubicin-induced cardiac, hepatic, and renal toxicities in rats, inhibiting increases in plasma cholesterol, LDH, and CK.
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