Why the study?
Doxorubicin causes cardiotoxicity via free radical production and cardiomyocyte injury, prompting evaluation of Rheum turkestanicum extract against this toxicity given its antioxidant activity.
Does Rheum turkestanicum extract reduce doxorubicin-induced cardiotoxicity in male Wistar rats?
Population
Male Wistar rats
Comparison
Rheum turkestanicum (100 and 300 mg/kg) vs doxorubicin alone
Design
Animal experimental study
Follow-up
15th day
Authors
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Supports hypothesis generation for herbal cardioprotection; leaves open clinical translation pending human trials.
Does Rheum turkestanicum extract reduce doxorubicin-induced cardiotoxicity in male Wistar rats?
Rheum turkestanicum extract demonstrates cardioprotective effects against doxorubicin-induced toxicity in a rat model by modulating oxidative stress.
Hosseini et al. (2022) studied this question.
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