Key result
Curcuma longa extracts completely abolished the 50% mortality induced by doxorubicin and significantly reduced markers of cardiac injury such as CK-MB and LDH in rats.
Why the study?
Does Curcuma longa extract prevent doxorubicin-induced cardiotoxicity in rats?
Population
96 male Sprague-Dawely rats weighing 200 to 250 g
Comparison
Curcuma longa ethanolic extract or water extract… vs Doxorubicin alone and normal saline control
Design
Preclinical, randomly assigned to eight groups
Follow-up
9 days
Authors
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Should not change doxorubicin cardiotoxicity management; hypothesis-generating in rats and leaves open human translation.
Does Curcuma longa extract prevent doxorubicin-induced cardiotoxicity in rats?
Absolute Event Rate: 0% vs 50%
Absolute Risk Reduction: 50%
p-value: p=<0.05
Curcuma longa extracts protect against doxorubicin-induced cardiotoxicity in rats by reducing oxidative stress and preserving antioxidant enzyme activities.
El-Sayed et al. (2011) studied Doxorubicin-induced cardiotoxicity (n=96). Curcuma longa L. extracts (ethanolic or water) vs. Doxorubicin alone was evaluated on Mortality rate (p=<0.05). Curcuma longa extracts completely abolished the 50% mortality induced by doxorubicin and significantly reduced markers of cardiac injury such as CK-MB and LDH in rats.
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