What question did this study set out to answer?

To determine whether host genetic background affects bacterial multiplication and delayed-type hypersensitivity in inbred mouse strains infected with low doses of Mycobacterium bovis BCG.

April 1, 1981Infection and ImmunityOpen Access

Differences in Response Among Inbred Mouse Strains to Infection with Small Doses of Mycobacterium bovis BCG

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Authors

AFA ForgetInstitut National de la Recherche Scientifique ESEmil SkameneShowa University PGPhilippe GrosThüringer Landesanstalt für Landwirtschaft

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Implication

In vivo study demonstrates divergent bacterial growth and splenomegaly across inbred mice exposed to BCG, indicating genetic resistance functions independently of delayed-type hypersensitivity.

Key Points

To determine whether host genetic background affects bacterial multiplication and delayed-type hypersensitivity in inbred mouse strains infected with low doses of Mycobacterium bovis BCG.
Infected six inbred mouse strains (C3H/HeCr, A/J, DBA/2, B10.A, C57BL/6, and BALB/c) intravenously with small dispersed doses of Mycobacterium bovis BCG at 15.5 x 10^3 or 15.5 x 10^4 colony-forming units.
Quantified bacterial multiplication in spleens at 28 days post-infection as the ratio of recovered to injected colony-forming units, and evaluated spleen enlargement and delayed-type hypersensitivity.
Strains bifurcated into resistant (C3H/HeCr, A/J, DBA/2) with a recovery coefficient <1 and sensitive (B10.A, C57BL/6, BALB/c) with a coefficient >2.5 at the lower infection dose.
Significant splenomegaly developed exclusively in the sensitive mouse strains relative to uninfected controls.
Delayed-type hypersensitivity showed no correlation with bacterial multiplication: it was absent across all strains at the lower dose, while both the most sensitive (BALB/c) and most resistant (C3H/HeCr) strains mounted responses at the higher dose.

Cite This Study

Forget et al. (1981) studied this question.

synapsesocial.com/papers/6a75e976fdf0921e0f78619f https://doi.org/10.1128/iai.32.1.42-47.1981

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Implication

In vivo study demonstrates divergent bacterial growth and splenomegaly across inbred mice exposed to BCG, indicating genetic resistance functions independently of delayed-type hypersensitivity.

Differences in Response Among Inbred Mouse Strains to Infection with Small Doses of Mycobacterium bovis BCG

Discussion

Member takes

Implication

Key Points

Cite This Study

Differences in Response Among Inbred Mouse Strains to Infection with Small Doses of Mycobacterium bovis BCG

Discussion

Member takes

Implication

Key Points

Cite This Study

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