Key result
A history of mTBI was associated with paradoxical sympathetic activation and increased blood pressure during 30 mm Hg eyeball pressure stimulation, unlike the parasympathetic shift seen in controls.
Why the study?
Does eyeball pressure stimulation unveil subtle autonomic cardiovascular dysfunction in persons with a history of mild traumatic brain injury compared to healthy controls?
Population
24 patients with a history of mild traumatic brain injury and 27 healthy controls. Total n=51.
Comparison
2 minutes of 30 mm Hg eyeball pressure… vs Healthy controls receiving the same eyeball…
Design
Case-control
Authors
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Suggests caution during ocular pressure testing in mTBI patients; leaves open whether this response predicts cardiovascular outcomes.
Case-Control (n=51)
Does eyeball pressure stimulation unveil subtle autonomic cardiovascular dysfunction in persons with a history of mild traumatic brain injury compared to healthy controls?
Eyeball pressure stimulation reveals paradoxical sympathetic activation in post-mTBI patients, suggesting central autonomic dysfunction that may contribute to long-term cardiovascular risk.
Hilz et al. (2015) conducted a case-control in Mild traumatic brain injury (n=51). History of mild traumatic brain injury vs. Healthy controls was evaluated on Changes in blood pressure and RRI spectral powers during eyeball pressure stimulation. A history of mTBI was associated with paradoxical sympathetic activation and increased blood pressure during 30 mm Hg eyeball pressure stimulation, unlike the parasympathetic shift seen in controls.
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