Vesicles prepared with synthetic amphiphiles (dioctadecyldimethylammonium bromide and chloride, dihexadecyl phosphate its sodium salt) were obtained by sonication, ethanol injections, and chloroform injections. The hydrodynamic diameter vesicles (Z)h), estimated from the diffusivity measured by quasielastic light scattering, ranged from 230 to 3000 . The mobility (£/m) was measured by free-flow electrophoresis. The zeta potential ({) and the degree of counterion (a) of the vesicles were calculated from Um and conductivity data, a decreased with increasing Dh of the vesicles, due to the decreasing headgroup area and the increasing counterion association needed to relax the surface electrostatic . The electrophoretic mobility was also calculated (Uc) according to an impenetrable, nonconducting sphere model a spherically symmetric charge distribution approximation. Within the limits of the experimental error(s) of the (different) employed and the assumptions made in the calculations, the fact that the t/m/t/c ratio ranged from 1.3 to 7.5 was to be a good agreement between the calculated and the experimental values.
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Cuccovia et al. (1990) studied this question.