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March 1, 2014European Journal of Microbiology and ImmunologyOpen Access

Human adenovirus: Viral pathogen with increasing importance

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Authors

BGBeniam GhebremedhinWitten/Herdecke University

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Overview

Review reveals severe ocular complications and limited therapeutic efficacy for human adenovirus infections, highlighting infection prevention as the primary clinical control strategy.

Key Points

  • To review the biology and epidemiology of human adenovirus and provide an update on the diagnosis, management, and prophylaxis of adenoviral ocular infections.
  • Synthesized virological and epidemiological data on human adenovirus serotypes associated with ocular syndromes.
  • Evaluated diagnostic methods including cell culture, antigen detection, immunochromatography, and polymerase chain reaction, along with current therapeutic options.
  • Human adenovirus produces two distinct ocular syndromes—epidemic keratoconjunctivitis and pharyngoconjunctival fever—that transmit through contact or fomites and peak in warmer months.
  • Infection frequently causes pseudomembranes and keratitis nummularis, leading to disproportionately severe disease in pediatric and immunocompromised individuals.
  • No evaluated antiviral therapies demonstrate complete efficacy against the virus, leaving rigorous hygiene and prophylactic barriers as the primary means of outbreak control.

Cite This Study

Beniam Ghebremedhin (2014) studied this question.

synapsesocial.com/papers/6a75eb7d7d7eb453cc707471https://doi.org/10.1556/eujmi.4.2014.1.2
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Also Consider

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  1. 1Adenovirus Type 7 Outbreaks in Japan in 19982000 · 7 citations
  2. 2Isolation of a Cytopathogenic Agent from Human Adenoids Undergoing Spontaneous Degeneration in Tissue Culture1953 · 1,122 citations
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  4. 4EPIDEMIOLOGY OF EPIDEMIC KERATOCONJUNCTIVITIS1987 · 179 citations
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