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January 1, 2018Sunhwan'giOpen Access

Protective Effect of Right Ventricular Mitochondrial Damage by Cyclosporine A in Monocrotaline-induced Pulmonary Hypertension

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Why the study?

Does cyclosporine A reduce right ventricular mitochondrial damage in monocrotaline-induced pulmonary hypertension in rats?

Population

Eight weeks old Sprague-Dawley rats with monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH)

Comparison

Cyclosporine A (CsA) 10 mg/kg/day for 4 weeks vs Control group and MCT (60 mg/kg) alone group

Design

Preclinical, randomized

Follow-up

4 weeks

Authors

DLDong Seok LeeYJYong Wook Jung

Discussion

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Overview

CsA may protect mitochondria in experimental PAH; leaves open translation to human disease.

Structured PICO

Does cyclosporine A reduce right ventricular mitochondrial damage in monocrotaline-induced pulmonary hypertension in rats?

P
Population
Eight weeks old Sprague-Dawley rats with monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH)
I
Intervention
Cyclosporine A (CsA) 10 mg/kg/day for 4 weeks
C
Comparator
Control group and MCT (60 mg/kg) alone group
O
Outcome
Right ventricular hypertrophy (RVH) and morphological changes of right ventricle (RV)surrogate

Cyclosporine A prevents right ventricular mitochondrial disruption and attenuates apoptosis markers in a rat model of pulmonary arterial hypertension, suggesting potential as an adjunctive therapy.

Cite This Study

Lee et al. (2018) studied this question.

synapsesocial.com/papers/6a75eecf49a8cdd61fb1e698https://doi.org/10.4070/kcj.2018.0061
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