The discovery of angiotensin‐converting enzyme 2 and its role in acute lung injury in mice
Why the study?
Does ACE2 protect against acute lung injury in mice?
Population
Mice (including ACE2 knockout mice)
Design
Preclinical
Authors
Discussion
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Member takes
Overview
Hypothesis-generating for ACE2 modulation in ARDS; leaves open translation to human SARS-CoV therapies.
Structured PICO
Does ACE2 protect against acute lung injury in mice?
P
Population
Mice (including ACE2 knockout mice)
I
Intervention
SARS-CoV Spike protein injection and/or blocking the renin-angiotensin pathway
O
Outcome
Acute lung injury / ARDS severitysurrogate
ACE2 plays a protective role in acute lung injury, and its downregulation by SARS-CoV Spike protein worsens lung failure, which can be mitigated by blocking the renin-angiotensin pathway.
Cite This Study
Imai et al. (2008) studied this question.