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February 1, 1999The Journal of ImmunologyOpen Access

Calcium-Dependent Activation of TNF Family Gene Expression by Ca2+/Calmodulin Kinase Type IV/Gr and Calcineurin

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Population

T lymphocytes and reporter gene assays using constructs driven by promoters of human CD40L, FasL, or TNF-alpha

Comparison

Co-expression of constitutively active CaMKIV… vs Individual expression or uninhibited state

Design

Preclinical

Authors

FLFrancis M. LoboYale UniversityRZReza ZanjaniNHNga HoCan Tho University

Discussion

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Implication

CaMKIV inhibition may modulate T-cell TNF cytokines; leaves open therapeutic translation from animal models to human disease.

Structured PICO

P
Population
T lymphocytes and reporter gene assays using constructs driven by promoters of human CD40L, FasL, or TNF-alpha
I
Intervention
Co-expression of constitutively active CaMKIV and calcineurin, or specific inhibition of CaMKIV (chemical or dominant negative mutant)
C
Comparator
Individual expression or uninhibited state
O
Outcome
Transcriptional activation of TNF family genes (CD40L, FasL, TNF-alpha) and protein expressionsurrogate

Activation of gene expression by calcineurin and CaMKIV is a common synergistic pathway for members of the TNF cytokine family in T cells.

Cite This Study

Lobo et al. (1999) studied this question.

synapsesocial.com/papers/6a75ef2e8d9f8f61228b7375https://doi.org/10.4049/jimmunol.162.4.2057
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells.1993 · 371 citations
  2. 2T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS1996 · 687 citations
  3. 3Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia.1993 · 802 citations
  4. 4Cyclosporin A inhibits CD40 ligand expression in T lymphocytes.1994 · 141 citations
  5. 5A Signaling Complex of Ca <sup>2+</sup> -Calmodulin-Dependent Protein Kinase IV and Protein Phosphatase 2A1998 · 231 citations