What question did this study set out to answer?

To evaluate local histopathologic tumor regression using serial biopsies as an objective measure of therapeutic success in prostate cancer patients treated with hormonal therapy or radiotherapy.

January 1, 1982The Prostate

Therapy of prostatic cancer and histopathologic follow‐up

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Authors

GDG. DhomLMU Klinikum SDS. DegroSaarland University

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Implication

Cohort study demonstrates superior tumor regression with radiotherapy for cribriform prostate cancer, indicating histological subtype dictates optimal treatment response.

Key Points

To evaluate local histopathologic tumor regression using serial biopsies as an objective measure of therapeutic success in prostate cancer patients treated with hormonal therapy or radiotherapy.
Followed 308 prostate cancer patients treated with estradiol or high-voltage radiotherapy between 1971 and 1981, using 1,138 punch biopsies and 155 transurethral resections (mean 4.2 biopsies per patient).
Stratified patients into acinar adenocarcinomas (n=130) and cribriform or solid carcinomas (n=178).
Applied a 10-point scoring scale to classify histopathologic regression into pronounced, moderate, and poor or no regression.
In acinar adenocarcinomas, pronounced regression occurred in 67.8% after ≥3 years of hormonal treatment and in 64.7% following high-voltage therapy, with poor or no regression in 20.4% and 14.7%, respectively.
In cribriform and solid carcinomas, pronounced regression occurred in 63.6% following radiotherapy versus 20.2% following hormonal therapy, while poor or no regression occurred in 21.3% versus 48.8%, respectively.
Conformity between locally palpable physical findings and histopathologic grading of regression reached 70%.

Cite This Study

Dhom et al. (1982) studied this question.

synapsesocial.com/papers/6a75ef4ed17bc701ee162e44 https://doi.org/10.1002/pros.2990030602

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Implication

Cohort study demonstrates superior tumor regression with radiotherapy for cribriform prostate cancer, indicating histological subtype dictates optimal treatment response.

Therapy of prostatic cancer and histopathologic follow‐up

Discussion

Member takes

Implication

Key Points

Cite This Study

Therapy of prostatic cancer and histopathologic follow‐up

Discussion

Member takes

Implication

Key Points

Cite This Study

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