Why the study?
Does ketorolac tromethamine improve safety and efficacy compared to aspirin in patients requiring long-term analgesic therapy for chronic pain?
Population
823 patients requiring long-term analgesic therapy for chronic pain
Comparison
Ketorolac tromethamine 10 mg 4 times a day as… vs Aspirin 650 mg 4 times a day as needed
Design
RCT, randomized, double-blind
Follow-up
52 weeks
Authors
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Supports ketorolac preference over aspirin for chronic pain; extends RCT evidence for long-term use.
Does ketorolac tromethamine improve safety and efficacy compared to aspirin in patients requiring long-term analgesic therapy for chronic pain?
Ketorolac tromethamine is favored over aspirin for long-term efficacy and safety in chronic pain management, with fewer withdrawals due to lack of efficacy.
Rubin et al. (1990) studied this question.
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