Key result
This ongoing randomized pilot trial aims to evaluate whether inaudible high-frequency sounds augment CBT for anhedonia in 44 adult patients, with 21 enrolled as of May 2019.
Why the study?
Anhedonia is associated with positive valence system deficits, and sound therapy enhances reward circuitry, suggesting a potential synergistic effect with cognitive behavioral therapy.
Does inaudible high-frequency sound therapy augment positive valence system-focused cognitive behavioral therapy to improve anhedonia in adult patients with moderate to severe depression?
Population
44 adult patients with clinically significant anhedonia and moderate to severe depression
Comparison
Positive valence system-focused CBT plus inaudible high-frequency sound vs CBT plus placebo sound
Design
Single-center masked randomized superiority pilot trial
Authors
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This pilot trial protocol outlines a study to evaluate whether inaudible high-frequency sounds can augment cognitive behavioral therapy for anhedonia in patients with depression.
RCT (n=44)
Triple-blind (patients, therapists, evaluators)
Individual-level allocation
No
Does inaudible high-frequency sound therapy augment positive valence system-focused cognitive behavioral therapy to improve anhedonia in adult patients with moderate to severe depression?
This pilot trial protocol outlines a study to evaluate whether inaudible high-frequency sounds can augment cognitive behavioral therapy for anhedonia in patients with depression.
Ito et al. (2019) conducted an RCT in Anhedonia and moderate to severe depression (n=44). Positive valence system-focused cognitive behavioral therapy with inaudible high-frequency sound vs. Cognitive behavioral therapy with placebo sound was evaluated on Anhedonia assessed using the self-reported Snaith-Hamilton Pleasure Scale. This ongoing randomized pilot trial aims to evaluate whether inaudible high-frequency sounds augment CBT for anhedonia in 44 adult patients, with 21 enrolled as of May 2019.
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