Key result
Omega-3 and Vitamin E significantly reduced the incidence of paclitaxel-induced peripheral neuropathy compared to placebo (28.6% and 33.3% vs 71.4%, p=0.0001).
Why the study?
Do omega-3 or vitamin E reduce the incidence of paclitaxel-induced peripheral neuropathy in patients receiving paclitaxel?
RCT (n=63)
Double-blind
Random number table
No
Do omega-3 or vitamin E reduce the incidence of paclitaxel-induced peripheral neuropathy in patients receiving paclitaxel?
Supplementation with omega-3 or vitamin E significantly reduces the incidence of paclitaxel-induced peripheral neuropathy compared to placebo.
Answers are grounded in this paper and cite their sources.
May support omega-3 or vitamin E to lower paclitaxel neuropathy risk; extends small RCT evidence for CIPN prevention.
BACKGROUND: Paclitaxel-induced peripheral neuropathy is the most important side effect limiting the use of this medication. AIM: This study aimed to compare the effects of omega-3 and vitamin E on the incidence of peripheral neuropathy in patients receiving Taxol. METHODS: In this clinical trial, 63 patients who were a candidate for receiving taxol, were enrolled based on inclusion and exclusion criteria. In group O, patients received 640 mg omega-3 three times a day, and group E, received 300 mg vitamin E two times a day. Patients took the supplements up to three months after the onset of Taxol. Group P received placebo for a similar period. All patients referred to a neurologist for electrophysiological evaluation before the onset of chemotherapy and at months 1 and 3. The presence of neuropathy and its progression was recorded by the neurologist. RESULTS: Neurological examination in this study indicated that 6 patients (28.6%) in Group O, 7 patients (33.3%) in group E, and 15 patients (71.4%) in placebo group started peripheral neuropathy. There was a significant difference between intervention groups and the placebo group (p = 0.0001) and no significant difference between intervention groups (p = 0.751). CONCLUSION: Our data suggested that vitamin E and omega-3 may significantly reduce the incidence of Paclitaxel-induced peripheral neuropathy. Routine administration of such supplements that have no special side effect for patients under chemotherapy may greatly enhance their quality of life.
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Anoushirvani et al. (2018) conducted an RCT in Paclitaxel-Induced Peripheral Neuropathy (n=63). Omega-3 and Vitamin E vs. Placebo was evaluated on Incidence of peripheral neuropathy (p=0.0001). Omega-3 and Vitamin E significantly reduced the incidence of paclitaxel-induced peripheral neuropathy compared to placebo (28.6% and 33.3% vs 71.4%, p=0.0001).
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