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Explore the significance of CD40 expression in bladder cancer and its correlation with clinical outcomes.

CD40 expression in bladder cancer

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Explore the significance of CD40 expression in bladder cancer and its correlation with clinical outcomes.
Examined CD40 expression immunohistochemically in 131 bladder transitional cell carcinomas.
Assessed correlation with prognostic markers and clinical outcomes.
Seventy-eight percent of tumors were CD40-positive, associated with lower stage and lower grade (p<0.001).
CD40 expression was present in 89% of Ta and T1 tumors, contrasting with 62% in T2-T4 tumors.
CD40 was not linked to other clinicopathological variables, suggesting alternative differentiation mechanisms.

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Randomized trial investigates CD40 expression's correlation with tumor behavior in bladder cancer, suggesting immunotherapy possibilities.

Cooke et al. (1999) studied this question.

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Randomized trial investigates CD40 expression's correlation with tumor behavior in bladder cancer, suggesting immunotherapy possibilities.