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July 1, 1986Microbiology and ImmunologyOpen Access

Production and Characterization of Monoclonal Strain‐Specific Antibodies against Prototype Strains of Rickettsia tsutsugamushi

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Population

Prototype strains of Rickettsia tsutsugamushi and 22 newly isolated strains from mites, field rodents, and…

Design

Preclinical

Authors

MMMichisato MURATAJichi Medical UniversityYYYoshiya YoshidaKanagawa Prefectural Institute of Public HealthMOMichiyo OsonoMicrobial Chemistry Research Foundation

Discussion

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Implication

May aid laboratory serotyping of R. tsutsugamushi; leaves open clinical diagnostic translation.

Structured PICO

P
Population
Prototype strains of Rickettsia tsutsugamushi (Gilliam, Karp, Kato) and 22 newly isolated strains from mites, field rodents, and patients with Tsutsugamushi disease in Japan
I
Intervention
Development of 18 hybridoma cell lines secreting murine monoclonal strain-specific antibodies
O
Outcome
Reactivity and specificity of monoclonal antibodies to homologous strainssurrogate

The developed monoclonal antibodies are highly specific to Rickettsia tsutsugamushi strains and can enhance serotyping and analytical investigation of rickettsial antigens.

Cite This Study

MURATA et al. (1986) studied this question.

synapsesocial.com/papers/6a75f0f17d7eb453cc7076cfhttps://doi.org/10.1111/j.1348-0421.1986.tb02987.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ANTIGENIC ANALYSIS BY DIRECT IMMUNOFLUORESCENCE OF 114 ISOLATES OF RICKETTSIA TSUTSUGAMUSHI RECOVERED FROM FEBRILE PATIENTS IN RURAL MALAYSIA1979 · 49 citations
  2. 2Direct Immunofluorescence for Typing of Tsutsugamushi Disease Rickettsia1965 · 18 citations
  3. 3Serological Diagnosis of Scrub Typhus by Indirect Immunofluorescence1963 · 132 citations
  4. 4USE OF MONOCLONAL ANTIBODIES IN THE ASSAY OF HEPATITIS B CORE ANTIGEN AND ANTIBODY1984 · 3 citations
  5. 5Analysis of polypeptide composition and antigenic components of Rickettsia tsutsugamushi by polyacrylamide gel electrophoresis and immunoblotting1985 · 99 citations