Answers are grounded in this paper and cite their sources.
Demonstrates altered lipid profiles, elevated homocysteine, and reduced antioxidant capacity in hypothyroid rats, suggesting an increased atherogenic risk.
This study focuses on the relationship between serum levels of cholesterol and homocysteine with that of total antioxidant capacity in rats with thyroid dysfunction. Adult male Wistar rats were divided into three groups, a control (euthyroid), hypothyroidism and hyperthyroidism , each of them containing ten rats. Hypothyroidism was induced by administration of 0.1% aminotriazole in drinking water for 3 weeks. Hyperthyroidism was induced by chronic subcutaneous injection of l -thyroxine (100 μg/day, dissolved in 200 μL saline solution/100 g body weight) for 3 weeks. The control and hypothyroid groups were injected subcutaneously with the same volume of saline solution. Results showed that hyperthyroidism is characterized by reduced serum thyroid stimulating hormone (TSH) levels despite increased free thyroxine (FT 4 ) and free triiodothyronine (FT 3 ) levels. Significant ( p < 0.05) elevation in serum levels of total homocysteine (t-Hcy) is reflected by a decrease in serum total antioxidant capacity (TAC) production in hypothyroidism comparing to control. There was a significant ( p < 0.05) elevation in serum levels of lipid profile (cholesterol, triglyceride and LDL) in hypothyroidism. Significant ( p < 0.05) reduction occurred in the levels of cholesterol and triglyceride in hyperthyroidism. The association of hyperhomocysteinemia and lipid abnormalities occurring in hypothyroidism may represent a dynamic atherogenic state.
No takes yet. Share an insight, caveat, or question.
Afaf Abbass Sayed Saleh (2015) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: