Why the study?
Abrupt withdrawal of anticoagulation tilts the balance toward a pro-thrombotic state, highlighting the need for awareness of rebound hypercoagulability and challenges in differentiating cardiac masses.
Population
A 60-year-old man with AFib who abruptly discontinued apixaban
Design
Case report
Authors
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Holding NOACs in AF may precipitate thrombosis; case report leaves open optimal interruption strategies.
Abrupt discontinuation of apixaban can cause a rebound hypercoagulable state, leading to the rapid formation of a large left atrial thrombus and severe thromboembolic events.
Niazi et al. (2021) studied this question.
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