November 1, 1997Diabetes

Evidence of an Increased Number of Type IIb Muscle Fibers in Insulin-Resistant First-Degree Relatives of Patients with NIDDM

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Population

25 first-degree relatives of NIDDM patients and 21 control subjects

Design

Case-control

Authors

BNB. NyholmAarhus University Hospital ZQZhuqing QuUniversity of Pittsburgh AKAndreas KaalAarhus University

Discussion

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Implication

Altered muscle fiber type may underlie familial insulin resistance; hypothesis-generating observation needing prospective validation.

Structured PICO

Population

25 first-degree relatives of NIDDM patients and 21 control subjects

Comparator

21 control subjects

Outcome

Muscle fiber composition (type IIb fibers) and insulin-stimulated glucose disposal (Rd)surrogate

Insulin-resistant first-degree relatives of NIDDM patients have an increased proportion of type IIb muscle fibers, which correlates with reduced insulin-stimulated glucose disposal.

Cite This Study

Nyholm et al. (1997) studied this question.

synapsesocial.com/papers/6a75fa04b59e1a4df67865e2 https://doi.org/10.2337/diab.46.11.1822

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Evidence of an Increased Number of Type IIb Muscle Fibers in Insulin-Resistant First-Degree Relatives of Patients with NIDDM

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evidence of an Increased Number of Type IIb Muscle Fibers in Insulin-Resistant First-Degree Relatives of Patients with NIDDM

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider