Why the study?
DOAC-associated ICH is a catastrophic complication, but the impact of CT-based SVD burden on DOAC-ICH and admission DOAC concentrations on ICH outcomes required investigation.
Is cerebral small vessel disease burden and admission DOAC level associated with the risk and severity of intracerebral hemorrhage in DOAC users?
Population
43 DOAC-ICH patients and 177 DOAC-non-ICH patients
Comparison
DOAC-ICH patients vs stable DOAC-non-ICH patients and across admission DOAC drug levels
Design
Two-cohort study
Follow-up
3 months
Authors
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Higher SVD burden was associated with DOAC-ICH and worse outcomes; leaves open whether CT-SVD scoring should inform anticoagulation decisions in AF.
Is cerebral small vessel disease burden and admission DOAC level associated with the risk and severity of intracerebral hemorrhage in DOAC users?
Higher cerebral small vessel disease burden and elevated admission DOAC levels are strongly associated with an increased risk and worse clinical outcomes of DOAC-associated intracerebral hemorrhage.
Lin et al. (2023) studied this question.