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March 19, 2021Journal of Neurology Neurosurgery & Psychiatry37 citationsOpen Access

Small vessel disease burden and intracerebral haemorrhage in patients taking oral anticoagulants

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Why the study?

Does small vessel disease burden predict intracerebral haemorrhage in patients taking oral anticoagulants for atrial fibrillation?

Population

1030 patients with intracerebral haemorrhage and 1447 patients with atrial fibrillation and cerebral…

Comparison

Presence of medium-to-high severity small vessel… vs Absence or low severity of small vessel disease

Design

Cohort

Follow-up

2 years

Authors

DSDavid SeiffgeDWDuncan WilsonGAGareth Ambler

Discussion

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Overview

Medium-to-high severity small vessel disease independently predicts intracerebral haemorrhage in patients taking anticoagulants for atrial fibrillation, suggesting anticoagulation alone is not the sole cause of ICH.

Structured PICO

Does small vessel disease burden predict intracerebral haemorrhage in patients taking oral anticoagulants for atrial fibrillation?

P
Population
1030 patients with intracerebral haemorrhage (ICH) (421 on anticoagulants) and 1447 patients with atrial fibrillation (AF) and cerebral ischaemia taking anticoagulants
I
Intervention
Presence of medium-to-high severity small vessel disease (SVD)
C
Comparator
Absence or low severity of small vessel disease (SVD)
O
Outcome
Intracerebral haemorrhage (ICH) and ischaemic strokehard clinical

Medium-to-high severity small vessel disease independently predicts intracerebral haemorrhage in patients taking anticoagulants for atrial fibrillation, suggesting anticoagulation alone is not the sole cause of ICH.

Cite This Study

Seiffge et al. (2021) studied this question.

synapsesocial.com/papers/6a7f6a4ecd143bfec98b6305https://doi.org/10.1136/jnnp-2020-325299
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Divergent Small Vessel Disease Burden in Warfarin-Associated and Direct Oral Anticoagulant-Associated Intracerebral Hemorrhage2026
  2. 2Small vessel disease is associated with an unfavourable outcome in stroke patients on oral anticoagulation2019 · 20 citations
  3. 3Impact of cerebral small vessel disease burden and drug level at admission on direct oral anticoagulant associated intracerebral hemorrhage2023 · 1 citations
  4. 4Cerebral Microbleeds on Magnetic Resonance Imaging and Anticoagulant-Associated Intracerebral Hemorrhage Risk2012 · 94 citations
  5. 5Impact of Intracranial Atherosclerosis and Cerebral Small Vessel Disease on Overt Vascular Events During Antithrombotic Therapy2026