Why the study?
Does Fas activation cause functional disturbances and apoptosis in ventricular myocytes, and can these effects be blocked by tyrosine kinase inhibition?
Does Fas activation cause functional disturbances and apoptosis in ventricular myocytes, and can these effects be blocked by tyrosine kinase inhibition?
Tyrosine phosphorylation may serve as a novel therapeutic target for attenuating Fas-mediated dysfunction and apoptosis in both normoxic and hypoxic myocardium.
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Tyrosine kinase inhibition may attenuate Fas-mediated myocyte apoptosis and dysfunction; leaves open translation to ischemic heart disease.
Binah et al. (2004) studied this question.
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