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July 16, 1982Science

The Anticancer Agent Adriamycin Can Be Actively Cytotoxic Without Entering Cells

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Why the study?

Does adriamycin coupled to an insoluble agarose support exert cytotoxic action on L1210 cells without entering the cell?

Population

L1210 cells in culture

Design

Preclinical

Authors

TTThomas R. TritonYale UniversityGYGene K. YeeTufts University

Discussion

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Implication

Challenges DNA as primary anthracycline target; leaves open surface-action relevance for clinical translation.

Structured PICO

Does adriamycin coupled to an insoluble agarose support exert cytotoxic action on L1210 cells without entering the cell?

P
Population
L1210 cells in culture
I
Intervention
Adriamycin coupled to an insoluble agarose support
O
Outcome
Cytotoxicitysurrogate

Adriamycin can exert its cytotoxic action solely by interaction at the cell surface, challenging the previous assumption that its principal target is DNA.

Cite This Study

Triton et al. (1982) studied this question.

synapsesocial.com/papers/6a7602b849a8cdd61fb1eb5ehttps://doi.org/10.1126/science.7089561
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Also Consider

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