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PURPOSE: To present a case in which iris pigmentation developed after treatment with isopropyl unoprostone, an analogue of a prostaglandin metabolite. METHODS: Case report. RESULTS: A Japanese man with dark brown irises, treated unilaterally with isopropyl unoprostone, developed iris-color change in the treated eye after a 20-month treatment. CONCLUSIONS: Isopropyl unoprostone can induce iris pigmentation as does latanoprost.
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Yamamoto et al. (1997) studied this question.
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