Correlation of inhibition of platelet aggregation after clopidogrel with post discharge bleeding events: assessment by different bleeding classifications
Why the study?
Does inhibition of platelet aggregation correlate with bleeding events in patients with CAD or ischaemic stroke on chronic low-dose aspirin plus clopidogrel?
Population
363 patients with documented coronary artery disease and previous ischaemic stroke treated with chronic…
Design
Cohort
Authors
Discussion
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Implication
May flag minor bleeding risk on DAPT; leaves open severe bleeding prediction and clinical utility.
Structured PICO
Does inhibition of platelet aggregation correlate with bleeding events in patients with CAD or ischaemic stroke on chronic low-dose aspirin plus clopidogrel?
P
Population
363 patients with documented coronary artery disease (n=246) and previous ischaemic stroke (n=117) treated with chronic low-dose aspirin plus clopidogrel.
I
Intervention
Measurement of 5 microM ADP-induced inhibition of platelet aggregation (IPA)
O
Outcome
Bleeding complications assessed by TIMI, GUSTO, and BleedScore scalessafety
Inhibition of platelet aggregation >50% on dual antiplatelet therapy strongly predicts minor bleeding events but is a poor predictor of severe bleeding.
Cite This Study
Serebruany et al. (2009) studied this question.