Key result
Brain SPECT detects severe cerebral hypoperfusion in ~36% of neurologically asymptomatic diabetic patients.
Cross-Sectional (n=78)
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We assessed cerebral blood flow in 78 diabetic patients (40 Type 1 and 38 Type 2) with no previous history of central nervous system disease using 99Tcm-hexamethylpropylene amine oxime (99Tcm-HMPAO) single photon emission tomography (SPET) and found areas of severe hypoperfusion in 36% of them. All cerebral anatomical regions showed abnormalities related to hypoperfusion, but they were most frequently seen in the fronto-temporal region, followed by the occipital and parietal regions. 99Tcm-HMPAO SPET has been shown to be able to detect subclinical alterations in blood flow in diabetes, a finding that may account for the high prevalence of cerebrovascular disease seen in these patients. This technique could, therefore, play an important role in future preventative strategies.
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Jiménez‐Bonilla et al. (1996) conducted a cross-sectional in Diabetes mellitus (Type 1 and Type 2) (n=78). 99Tcm-HMPAO single photon emission tomography (SPET) was evaluated on Areas of severe cerebral hypoperfusion. 99Tcm-HMPAO SPET detected areas of severe cerebral hypoperfusion in 36% of diabetic patients without a clinical history of neurological disease.
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