November 30, 2011The FASEB Journal

Mice expressing T4826I‐RYR1 are viable but exhibit sex‐ and genotype‐dependent susceptibility to malignant hyperthermia and muscle damage

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Population

Knock-in mouse line expressing the isogenetic mutation T4826I in the type 1 ryanodine receptor and wild-type…

Comparison

Exposure to environmental heat stress and… vs Wild-type (WT) mice exposed to the same conditions

Design

Preclinical

Follow-up

up to 12 months

Authors

BYBenjamin YuenSunesis (United States)SBSimona BoncompagniUniversity of Chieti-Pescara WFWei FengQingdao University

Discussion

Member takes

Implication

Hypothesis-generating for RYR1-related MH susceptibility; leaves open human translation and sex-specific perioperative risks.

Structured PICO

Population

Knock-in mouse line expressing the isogenetic mutation T4826I in the type 1 ryanodine receptor (heterozygous RYR1 T4826I/+ or homozygous RYR1 T4826I/T4826I) and wild-type (WT) mice

Intervention

Exposure to environmental heat stress (37°C or 41°C) and pharmacological stress (1.75% halothane anesthesia on a 37°C or 41°C bed)

Comparator

Wild-type (WT) mice exposed to the same conditions

Outcome

Development of fulminant malignant hyperthermia

The T4826I-RYR1 mutation in mice confers a genotype- and sex-dependent susceptibility to malignant hyperthermia triggered by heat and halothane, as well as progressive myopathy.

Cite This Study

Yuen et al. (2011) studied this question.

synapsesocial.com/papers/6a760904a8fe27fd4294ad53 https://doi.org/10.1096/fj.11-197582

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Mice expressing T4826I‐RYR1 are viable but exhibit sex‐ and genotype‐dependent susceptibility to malignant hyperthermia and muscle damage

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mice expressing T4826I‐RYR1 are viable but exhibit sex‐ and genotype‐dependent susceptibility to malignant hyperthermia and muscle damage

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider